Expression of the Human Aryl Hydrocarbon Receptor Complex in Yeast

Cell Lines Hydrocarbon Responsiveness in Human Ovarian Carcinoma Characterization of the Aryl Hydrocarbon Receptor and Aryl

The human ovarian carcinoma cell lines PE01, PE04, and PE06 express the estrogen receptor and studies with the PE04 cells have shown that tamoxifen inhibits 17ß-estradiol-induced proliferation. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a broad spectrum antiestrogen which works through the aryl hydrocarbon receptor. Incubation of the three cell lines with | 'II11 ( 1)1) followed by isolatio...

Characterization of the Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Responsiveness in Human Ovarian Carcinoma Cell Lines1

The human ovarian carcinoma cell lines PE01, PE04, and PE06 express the estrogen receptor and studies with the PE04 cells have shown that tamoxifen inhibits 17ß-estradiol-induced proliferation. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a broad spectrum antiestrogen which works through the aryl hydrocarbon receptor. Incubation of the three cell lines with | 'II11 ( 1)1) followed by isolatio...

Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex.

In a previous cross-linking study we have shown that the cytosolic aryl hydrocarbon receptor (AhR) complex has a heterotetrameric structure (Perdew, G. H. (1992) Biochem. Biophys. Res. Commun. 182, 55-62). In this report, both cross-linked and [35S]methionine-labeled Hepa 1c1c7 cytosol were used to characterize the subunit composition of the AhR complex by immunoprecipitation with an AhR polycl...

Aryl Hydrocarbon Receptor Activation

The aryl hydrocarbon receptor in tumor immunity

The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR. Thus, this pathway represents an importan...